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L-Arginine L-Pyroglutamate 250 Grams


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ADP: $39.99
Price: $15.99
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Manufacturer: *Supplement Direct*
Manufacturer Part No: 7348900336
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Arginine Pyroglutamate is a compound wherein the amino acid arginine is molecularly bonded to a pyroglutamate molecule. Pyroglutamate is a naturally occurring amino acid that can be derived in nature from vegetables, fruit, dairy products and meat. This promotes HGH levels and increased nitric oxide production for enhanced blood flow and better delivery of oxygen and nutrients to working muscle. This product increases the optimal levels of nitric oxide in the body, a potent neurotransmitter associated with memory. Nitric oxide works by dilating blood vessels, thus improving blood flow to the brain. Because of this, Pyroglutamate can be used to improve memory and learning. Aside from those already mentioned benefits, if you are involved in intense physical activity or exercise, using pyroglutamate arginine will also help through its action of increasing NO levels in the body.

Arginine stimulates the natural production of growth hormone as well and is a far safer and more cost effective alternative to growth hormone treatment. grwoth hormone  is one of the most powerful hormones in the human body which makes the growth of lean muscle tissue possible while at the same time promoting the loss of fat. As you age, growth hormone levels drop, which is among the main reasons why we all tend to lose muscle and gain fat as we get older. In a controlled trial, when arginine and other amino acids were used in conjunction with a weight training program, more decrease in body fat was achieved after only five weeks than when the same exercise was done on a placebo group. Arginine is required to improve protein synthesis, which in turn can increase and speed up muscle growth. L-Arginine L-Pyroglutamate was on the spotlight back in 1981 when Italian researcher A. Isidori, M.D., and his colleagues of the University of Rome found out that a combination of L-Lysine  and L-Arginine L-Pyroglutamate, when given orally to a group of 15 male volunteers between the 15 and 20 years old, was more than 10 times more effective at increasing blood levels human growth hormone than taking only the amino acid L-Arginine by itself (an average net HGH yield increase of more than 700%).

250 Grams

Supplement Facts
Serving Size 1/2 Level Teaspoon 1 grams
Servings Per Container 250

Amount Per Serving
% Daily Value

Calories
4

Total Fat
0

Saturated Fat
0g

Cholesterol
0g

Sodium
0g

Potassium
0g

Total Carbohydrates
0g

Dietary Fiber
0g

Sugars
0g

Protein
1g


Ingredients
Pure HPLC Tested L-Arginine L-Pyroglutamate



Not A Significant Source Of Any Vitamins.

What is L-Arginine L-Pyroglutamate (APG)?

Intense and strenuous physical activity over long periods of time can deprive the brain of the energy required for proper functioning. Taking oral L-Arginine L-Pyroglutamate is beneficial because it can cross the blood brain barrier and enter into the brain where it triggers energetic processes in the brain and enhances cognitive functions. Pyroglutamate has numerous remarkable cognitive-enhancing effects. Clinical studies of pyroglutamate have shown that it improves memory, helps fight the effects of alcohol, and combats senility. Arginine (or L-arginine) is a crystalline free-form amino acid found and directly involved in a number of human processes and biochemistry, including muscle metabolism, ammonia detoxification, hormone secretion and the immune system. L-arginine is considered a semi-essential amino acid, because although the body can make its own supply and it is normally manufactured in sufficient amounts within the body, supplementation is sometimes required, as in the case of severe wounds or diseases. Arginine supports protein synthesis as it is required in the transport and storage of nitrogen and it is also critical for proper and high physical performance because it is used by the body to produce creatine.

Arginine Pyroglutamate is a compound wherein the amino acid arginine is molecularly bonded to a pyroglutamate molecule. Pyroglutamate is a naturally occurring amino acid that can be derived in nature from vegetables, fruit, dairy products and meat. This promotes HGH levels and increased Nitric oxide production for enhanced blood flow and better delivery of oxygen and nutrients to working muscle. This product increases the optimal levels of nitric oxide in the body, a potent neurotransmitter associated with memory. Nitric oxide works by dilating blood vessels, thus improving blood flow to the brain. Because of this, Pyroglutamate can be used to improve memory and learning. Aside from those already mentioned benefits, if you are involved in intense physical activity or exercise, using pyroglutamate arginine will also help through its action of increasing NO levels in the body.

Arginine stimulates the natural production of growth hormone as well and is a far safer and more cost effective alternative to growth hormone treatment.  growth hormone is one of the most powerful hormones in the human body which makes the growth of lean muscle tissue possible while at the same time promoting the loss of fat. As you age, growth hormone levels drop, which is among the main reasons why we all tend to lose muscle and gain fat as we get older. In a controlled trial, when arginine and other amino acids were used in conjunction with a weight training program, more decrease in body fat was achieved after only five weeks than when the same exercise was done on a placebo group. Arginine is required to improve protein synthesis, which in turn can increase and speed up muscle growth. L-Arginine L-Pyroglutamate was on the spotlight back in 1981 when Italian researcher A. Isidori, M.D., and his colleagues of the University of Rome found out that a combination of L-Lysine and L-Arginine L-Pyroglutamate, when given orally to a group of 15 male volunteers between the 15 and 20 years old, was more than 10 times more effective at increasing blood levels human growth hormone than taking only the amino acid L-arginine alone  (an average net HGH yield increase of more than 700%).

In the United States, L-Arginine is sold as a dietary supplement, and dietary supplements are regulated as foods, not drugs. Therefore, premarket evaluation and approval by the Food and Drug Administration are not required unless claims are made for specific disease prevention or treatment.
Health Benefits of L-Arginine L-Pyroglutamate
 
L-arginine is necessary to manufacture nitric oxide, a secondary messenger involved in blood flow. Nitric oxide is a chemical substance that ensures blood vessels are dilated to promote healthy blood flow. There is enough evidence demonstrating arginine’s use in the treatment of medical conditions that are improved by vasodilation, such as angina, atherosclerosis, coronary artery disease, erectile dysfunction, heart failure, intermittent claudication/peripheral vascular disease, and vascular headache. Arginine also triggers protein synthesis and has been researched for its role and benefits in wound healing, bodybuilding, enhancement of sperm production (spermatogenesis), and prevention of wasting in people with critical illness. L-Arginine can siginificantly help for overall cardiovascular maintenance and sexual function as well as other processses that depend on a healthy circulatory status for the most part.

Although it has been first isolated way back in 1886, it was only in 1932 when scientists learned that L-arginine is needed to create urea, a waste product that is necessary for toxic ammonia to be removed from the body. In 1939, researchers discovered that L-arginine is also necessary to manufacture creatine. Creatine supplements and aids athletes in increasing muscle mass significantly, improving high-energy sports performance, increasing energy levels and speeding up recovery. Arginine helps inhibit creatine breaking down into creatinine at a constant rate, so that people who train can use this creatine in their intense training sessions and benefit from this top supplement by developing strength and stimulating muscle growth instead of it being cleared from the body by the kidneys. Arginine is also a precursor of guanido-phosphate, phosphor-arginine and creatine, the high-energy substances found and needed in muscles. L-Arginine has been used largely by bodybuilders to improve blood flow to their muscle tissue while enhancing creatine storage at the same time in the body. Arginine also plays an important role in muscle metabolism and works to transport, store and excrete nitrogen.
Potential Side Effects of L-Arginine L-Pyroglutamate

Side effect from higher doses of L-Arginine L-Pyroglutamate principally involve gastric upset. Pyroglutamate is a naturally occurring amino acid found in vegetables, fruit, dairy products and meat. There are no serious side effects as both are amino acids that are present in the foods commonly consumed by people on a daily basis. If taken in the recommended dosage of one and one-half to two grams of L-Arginine L-Pyroglutamate no side effects should result. However if you have kidney or liver disease you should consult your physician before taking any supplements. Arginine cannot be suggested as a supplement during pregnancy or breastfeeding because there is not enough scientific information available.

Recommended Dosage of L-Arginine L-Pyroglutamate

Recommended dose for L-Arginine L-Pyroglutamate vary between 1-3 grams daily. One half level teaspoon will supply approximately 1000 milligrams, or just about 1 grams. 

ALWAYS consult your doctor or pharmacist. Do not use any dietary supplement as a replacement for conventional care, or as a reason to postpone seeing a doctor about a medical problem. Tell all your health care providers about any complementary and alternative practices you use. Give them a full picture of what you do to manage your health. This will help ensure coordinated and safe care.

Common Effects of L-Arginine L-Pyroglutamate

• Supports protein synthesis
• Increases blood flow to the brain and improves cognitive functions
• Boosts circulatory health
• Increases level of nitric oxide for muscle tissue
• Promotes healthy sexual function
• Improves nutrient delivery
• Promotes higher HGH levels

Bioavailability, Mixing and Solubility of L-Arginine L-Pyroglutamate

This product dissolves quickly in hot water and somewhat more slowly in cold water. It has a much pleasing taste better than those of L-Arginine HCl And L-Arginine Base. When taking L-Arginine L-Pyroglutamate as a plain powder it is best to mix your usual dose with strongly flavored beverage or citrus juice before drinking.

References & Further Research

Pyroglutamic Acid Improves the Age Associated Memory Impairment
In human subjects, pyroglutamate was compared with placebo in a randomized double-blind trial for assessing its efficacy in treating memory deficits in 40 aged subjects. Twenty subjects were treated with pyroglutamate and 20 with placebo over a period of 60 days. Memory functions were evaluated at baseline and after 60 days of treatment by means of a test made up of six memory tasks. The results show that pyroglutamate is effective in improving verbal memory functions in subjects affected by age-related memory decline.

Pyroglutamic acid improves the age associated memory impairment
Pyroglutamate has a number of remarkable cognitive-enhancing effects. Clinical studies of pyroglutamate have demonstrated that it enhances memory, helps combat the effects of alcohol, and combats senility.

Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation
Three small double-blind, placebo-controlled studies enrolling a total of about 70 individuals with congestive heart failure found that oral arginine at a dose of 5 to 15 g daily could significantly improve symptoms as well as objective measurements of heart function.

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