Agmatine Sulfate 50 grams

ADP: $19.99

Price: $9.99

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Manufacturer: *Supplement Direct*

Manufacturer Part No: 734890109009

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Pharmaceutical Grade Agmatine Sulfate. Supplementing your diet with Agmatine Sulfate may promote: Enhanced Nitric Oxide Production. Agmatine Sulfate is an incredible compound capable of helping promote beneficial body changes in many ways. Agmatine Sulfate has been shown to increase Nitric Oxide, and reduce blood sugar levels, and support overall workout perfrmance.

Directions

Preworkout: As a dietary supplement, mix 1 scoop (1000mg) of Agmatine Sulfate with your pre-workout beverage of choice (such as water, Hemavol Protean or Conquer) and consume approximately 20-45 minutes before beginning your workout. Before Meals: As a dietary supplement, mix 1 serving of Agmatine Sulfate with your drink of choice (such as water or juice) or add it to any pre-workout youare currently using to increase it effectiveness. Consume it approximately 20-30 minutes prior to workout or exercise event. An additional 20g of carbohydrates will also support pre-workouot or exercise enhancement. Before Bed: As a dietary supplement, mix 1 serving of Agmatine Sulfate with your drink of choice night time protein supplement.

Warnings

Exceeding the recommended servings, not following the directions, or not following the warnings may lead to unwanted effects. This product is only intended to be consumed by healthy adults 18 years of age or older. Consult your health care professional before using this or any other dietary supplement. Follow label directions and do not exceed suggested dosages under any circumstances. This product should not be used by people with the following (but not limited to) conditions: cardiovascular disease, heart disease, renal or hepatic disease, people who have high or low blood pressure, diabetes or who are being treated for erectile dysfunction, people taking any medications for any psychiatric or mental disorder or by people who are pregnant or attempting to become pregnant. Not for use by nursing mothers. Discontinue use immediately if excessive sleeplessness, tremors, dizziness, nervousness, headaches, or heart palpitations occur. Do not use if the seal is broken or missing. Keep out of reach of children.

Nutrition Facts Serving Size 1/4 Teaspoon Servings Per Container 50

Amount Per Serving

	Serving	% DV
Agmatine Sulfate (99% Pure)	1000 mg	-



*percent Daily Values are based on a 2,000 calorie diet.


*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Agmatine is derived from L-arginine through decarboxylation (the removal of a carboxylic acid group). It is stored in neurons and is released during neuronal activation. Agmatine is considered to be a neurotransmitter and neuromodulator.

Preliminary research suggests agmatine has potential use in the treatment of neuropathic pain and drug addiction. It also protects the brain from toxins and strokes.

Though supplementing agmatine by itself can increase the perception of pain, it works synergistically with painkillers like morphine and fentanyl. Agmatine’s synergy with opioids allows it to reduce pain killer tolerance, the possibility of addiction, and pain itself.

Agmatine has several mechanisms. It can inhibit N-methyl-D-aspartate (NMDA) and nicotinic acetylcholine receptors, as well as activate imidazoline receptors. Agmatine can also inhibit nitric oxide synthase enzymes, which allows it to regulate elevated levels of nitric oxide. Agmatine can inhibit calcium channels and certain serotonin receptors as well. Further research is needed to determine the full extent of agmatine’s mechanisms.

There is a lot of animal evidence to suggest agmatine is a highly promising research chemical. It is not a common supplement because there is a lack of human evidence for its effects. Several studies have been done on people, but the majority use agmatine injections, not oral ingestion. Research must establish that agmatine’s effects will work following oral ingestion in order for wide-scale supplementation to be considered.

Long-term (5 years), high daily dosage of dietary agmatine--evidence of safety: a case report.

Gilad GM1, Gilad VH

Abstract

There is presently a great interest in the therapeutic potential of agmatine, decarboxylated arginine, for various diseases. Recent clinical studies have already shown that oral agmatine sulfate given for up to 3 weeks provides a safe and, as compared with current therapeutics, more effective treatment for neuropathic pain. These studies have ushered in the use of dietary agmatine as a nutraceutical. However, in view of information paucity, assessment of long-term safety of oral agmatine treatment is now clearly required. The authors of this report undertook to assess their own health status during ongoing consumption of a high daily dosage of oral agmatine over a period of 4-5 years. A daily dose of 2.67 g agmatine sulfate was encapsulated in gelatin capsules; the regimen consists of six capsules daily, each containing 445 mg, three in the morning and three in the evening after meals. Clinical follow-up consists of periodic physical examinations and laboratory blood and urine analyses. All measurements thus far remain within normal values and good general health status is sustained throughout the study period, up to 5 years. This case study shows for the first time that the recommended high dosage of agmatine may be consumed for at least 5 years without evidence of any adverse effects. These initial findings are highly important as they provide significant evidence for the extended long-term safety of a high daily dosage of dietary agmatine--a cardinal advantage for its utility as a nutraceutical.